Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 5 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 4269
Sealed predictions
- DOCK3 in dopamine neurons, braak+0.23 (p 0.545) → +0.32 (p 0.400)receipt 4276
- DOCK3 in oligodendrocytes, braak+0.49 (p 0.181) → +0.29 (p 0.456)receipt 4275
Swarm cases
receipt 4276: DOCK3 in dopamine neurons, braak
- power
- full sample +0.33 (p 0.188, n 18), 95% CI -0.17 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.38 (p 0.120, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.105, n 18). could be the mix.
- skeptic
- leave-one-out range +0.26 to +0.47, sign flips 0; without severely affected donors +0.33 (p 0.188, n 18). fragile.
- cell type
- strongest in astrocytes: -0.66 (p 0.0031, n 18) vs +0.33 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DOCK3 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up DOCK3 · astrocytes · braak: substantia nigra, an independent cohort (already registered)
receipt 4275: DOCK3 in oligodendrocytes, braak
- power
- full sample +0.41 (p 0.091, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.44 (p 0.070, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.47 (p 0.050, n 18). not the mix.
- skeptic
- leave-one-out range +0.34 to +0.54, sign flips 0; without severely affected donors +0.41 (p 0.091, n 18). robust.
- cell type
- strongest in astrocytes: -0.66 (p 0.0031, n 18) vs +0.41 in oligodendrocytes. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DOCK3 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up DOCK3 · astrocytes · braak: substantia nigra, an independent cohort: not measured
Receipts
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