Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody: collagenase clostridium histolyticum, ocriplasmin | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 773 | 0.82 |
| pathways Reactome | 15 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 11386
Sealed predictions
- COL5A1 in dopamine neurons, braak-0.11 (p 0.787) → -0.53 (p 0.145)receipt 11393
Swarm cases
receipt 11393: COL5A1 in dopamine neurons, braak
- power
- full sample -0.33 (p 0.176, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.33 (p 0.176, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.031, n 18). not the mix.
- skeptic
- leave-one-out range -0.46 to -0.25, sign flips 0; without severely affected donors -0.33 (p 0.176, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for COL5A1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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