parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.04 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in cdc	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	6 Parkinson's papers of 1,281	0.74
pathways Reactome	1 pathway; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 5946

receipt 5985: CIITA in dopamine neurons, braak

power: full sample -0.44 (p 0.066, n 18), 95% CI -0.75 to +0.03. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.46 (p 0.055, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.025, n 18). not the mix.
skeptic: leave-one-out range -0.60 to -0.38, sign flips 0; without severely affected donors -0.44 (p 0.066, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CIITA in dopamine neurons.

case closed: nothing better to follow up.

receipt 5984: CIITA in microglia, braak

power: full sample +0.22 (p 0.379, n 18), 95% CI -0.27 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.21 (p 0.403, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.17 (p 0.504, n 18). could be the mix.
skeptic: leave-one-out range +0.11 to +0.35, sign flips 0; without severely affected donors +0.22 (p 0.379, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CIITA in microglia.

case closed: nothing better to follow up.

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