Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 13 Parkinson's papers of 2,445 | 0.65 |
| pathways Reactome | 3 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 4277
Sealed predictions
- CHM in dopamine neurons, braak+0.62 (p 0.073) → +0.36 (p 0.347)receipt 4284
Swarm cases
receipt 4284: CHM in dopamine neurons, braak
- power
- full sample +0.41 (p 0.091, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.52 (p 0.028, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.55 (p 0.018, n 18). not the mix.
- skeptic
- leave-one-out range +0.32 to +0.57, sign flips 0; without severely affected donors +0.41 (p 0.091, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHM in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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