parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.06 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in hepatocytes	0.75
chemistry Open Targets	a small-molecule pocket: pegcetacoplan, al-78898a, amy-101	0.60
trials ClinicalTrials.gov	15 Parkinson's trials, 1 stopped	0.95
literature PubMed	185 Parkinson's papers of 70,505	0.31
pathways Reactome	11 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 4327

receipt 4335: C3 in dopamine neurons, braak

power: full sample -0.10 (p 0.696, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.08 (p 0.767, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.09 (p 0.709, n 18). could be the mix.
skeptic: leave-one-out range -0.25 to +0.03, sign flips 2; without severely affected donors -0.10 (p 0.696, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for C3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4334: C3 in microglia, braak

power: full sample +0.25 (p 0.315, n 18), 95% CI -0.24 to +0.64. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.32 (p 0.191, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.30 (p 0.221, n 18). could be the mix.
skeptic: leave-one-out range +0.15 to +0.43, sign flips 0; without severely affected donors +0.25 (p 0.315, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for C3 in microglia.

case closed: nothing better to follow up.

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