Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in epicardial cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 1,166 | 0.76 |
| pathways Reactome | 3 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 7620
Sealed predictions
- C1R in dopamine neurons, braak-0.38 (p 0.309) → -0.51 (p 0.165)receipt 7628
- C1R in astrocytes, braak-0.70 (p 0.036) → +0.26 (p 0.502)receipt 7627
Swarm cases
receipt 7628: C1R in dopamine neurons, braak
- power
- full sample -0.43 (p 0.072, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.39 (p 0.109, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.59 (p 0.010, n 18). not the mix.
- skeptic
- leave-one-out range -0.58 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.072, n 18). robust.
- cell type
- strongest in oligodendrocytes: -0.59 (p 0.0092, n 18) vs -0.43 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for C1R in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up C1R · oligodendrocytes · braak: substantia nigra, an independent cohort (already registered)
receipt 7627: C1R in astrocytes, braak
- power
- full sample -0.17 (p 0.498, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.17 (p 0.498, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.30 (p 0.221, n 18). could be the mix.
- skeptic
- leave-one-out range -0.32 to -0.06, sign flips 0; without severely affected donors -0.17 (p 0.498, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.59 (p 0.0092, n 18) vs -0.17 in astrocytes. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for C1R in astrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up C1R · oligodendrocytes · braak: substantia nigra, an independent cohort: not measured
Receipts
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