Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.20 (overall 0.14) | 0.20 |
| cell type Human Protein Atlas | cell type enhanced in brain excitatory neurons (101 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | 6 Parkinson's trials, 2 stopped | 0.73 |
| literature PubMed | 13 Parkinson's papers of 1,875 | 0.65 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2218
Sealed predictions
- BSN in dopamine neurons, braak-0.37 (p 0.329) → -0.67 (p 0.048)receipt 2224
Swarm cases
receipt 2224: BSN in dopamine neurons, braak
- power
- full sample -0.38 (p 0.120, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.36 (p 0.137, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.013, n 18). not the mix.
- skeptic
- leave-one-out range -0.47 to -0.30, sign flips 0; without severely affected donors -0.38 (p 0.120, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BSN in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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