parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.46 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (1141 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 0360

receipt 0368: BMP2K in dopamine neurons, braak

power: full sample +0.16 (p 0.532, n 18), 95% CI -0.33 to +0.58. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.14 (p 0.585, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.03 (p 0.922, n 18). could be the mix.
skeptic: leave-one-out range +0.08 to +0.33, sign flips 0; without severely affected donors +0.16 (p 0.532, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for BMP2K in dopamine neurons.

case closed: nothing better to follow up.

receipt 0367: BMP2K in microglia, braak

power: full sample +0.27 (p 0.281, n 18), 95% CI -0.23 to +0.65. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.31 (p 0.207, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.52 (p 0.027, n 18). not the mix.
skeptic: leave-one-out range +0.17 to +0.44, sign flips 0; without severely affected donors +0.27 (p 0.281, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for BMP2K in microglia.

case closed: nothing better to follow up.

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