Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.21 (overall 0.13) | 0.21 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (esophageal apical cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 65 | 0.91 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2265
Sealed predictions
- B3GNT3 in dopamine neurons, braak-0.69 (p 0.038) → -0.31 (p 0.414)receipt 2271
Swarm cases
receipt 2271: B3GNT3 in dopamine neurons, braak
- power
- full sample -0.41 (p 0.093, n 18), 95% CI -0.73 to +0.07. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.40 (p 0.097, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.58 (p 0.011, n 18). not the mix.
- skeptic
- leave-one-out range -0.52 to -0.34, sign flips 0; without severely affected donors -0.41 (p 0.093, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for B3GNT3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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