Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.04 (overall 0.03) | 0.04 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in ependymal cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6947
Sealed predictions
- B3GLCT in dopamine neurons, braak+0.64 (p 0.064) → +0.19 (p 0.631)receipt 6954
Swarm cases
receipt 6954: B3GLCT in dopamine neurons, braak
- power
- full sample +0.49 (p 0.038, n 18), 95% CI +0.03 to +0.78. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.46 (p 0.057, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.066, n 18). could be the mix.
- skeptic
- leave-one-out range +0.41 to +0.57, sign flips 0; without severely affected donors +0.49 (p 0.038, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for B3GLCT in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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