parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in esophageal apical cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	2 Parkinson's trials, 0 stopped	1.00
literature PubMed	2 Parkinson's papers of 1,549	0.85
pathways Reactome	5 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 7320

ANGPTL4 in dopamine neurons, braak+0.43 (p 0.244) → -0.03 (p 0.929)receipt 7327
ANGPTL4 in astrocytes, braak+0.11 (p 0.787) → +0.06 (p 0.875)receipt 7326

receipt 7327: ANGPTL4 in dopamine neurons, braak

power: full sample +0.18 (p 0.465, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.29 (p 0.246, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.29 (p 0.235, n 18). could be the mix.
skeptic: leave-one-out range +0.09 to +0.28, sign flips 0; without severely affected donors +0.18 (p 0.465, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ANGPTL4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7326: ANGPTL4 in astrocytes, braak

power: full sample +0.05 (p 0.847, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.00 (p 0.990, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.01 (p 0.976, n 18). could be the mix.
skeptic: leave-one-out range -0.07 to +0.17, sign flips 4; without severely affected donors +0.05 (p 0.847, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ANGPTL4 in astrocytes.

case closed: nothing better to follow up.

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