parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocyte progenitor cells (113 nCPM)	1.00
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 48	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 7325

ADGRB1 in dopamine neurons, braak-0.59 (p 0.098) → -0.18 (p 0.646)receipt 7333
ADGRB1 in oligodendrocytes, braak+0.04 (p 0.909) → -0.49 (p 0.186)receipt 7332

receipt 7333: ADGRB1 in dopamine neurons, braak

power: full sample -0.37 (p 0.135, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.38 (p 0.123, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.027, n 18). not the mix.
skeptic: leave-one-out range -0.48 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.135, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ADGRB1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7332: ADGRB1 in oligodendrocytes, braak

power: full sample -0.23 (p 0.360, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.23 (p 0.351, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.29 (p 0.250, n 18). could be the mix.
skeptic: leave-one-out range -0.41 to -0.13, sign flips 0; without severely affected donors -0.23 (p 0.360, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ADGRB1 in oligodendrocytes.

case closed: nothing better to follow up.

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