Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocyte progenitor cells (144 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 15 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 10179
Sealed predictions
- ACAP3 in dopamine neurons, braak-0.55 (p 0.122) → -0.60 (p 0.090)receipt 10187
- ACAP3 in oligodendrocytes, braak-0.72 (p 0.028) → -0.28 (p 0.459)receipt 10186
Swarm cases
receipt 10187: ACAP3 in dopamine neurons, braak
- power
- full sample -0.64 (p 0.0040, n 18), 95% CI -0.85 to -0.25. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.63 (p 0.0055, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.62 (p 0.0064, n 18). not the mix.
- skeptic
- leave-one-out range -0.69 to -0.60, sign flips 0; without severely affected donors -0.64 (p 0.0040, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ACAP3 in dopamine neurons.
case closed: nothing better to follow up.
receipt 10186: ACAP3 in oligodendrocytes, braak
- power
- full sample -0.43 (p 0.072, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.072, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.39 (p 0.107, n 18). could be the mix.
- skeptic
- leave-one-out range -0.61 to -0.37, sign flips 0; without severely affected donors -0.43 (p 0.072, n 18). robust.
- cell type
- strongest in dopamine neurons: -0.64 (p 0.0040, n 18) vs -0.43 in oligodendrocytes. proposing dopamine neurons.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ACAP3 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ACAP3 · dopamine neurons · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.15 p 0.594 (needs p < 2.1e-4)
Receipts
loading the receipts