parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.04 (overall 0.08)	0.04
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in adipocytes	0.75
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 516	0.85
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 3429

receipt 3437: ABCD2 in dopamine neurons, braak

power: full sample +0.21 (p 0.393, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.23 (p 0.365, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.261, n 18). could be the mix.
skeptic: leave-one-out range +0.13 to +0.38, sign flips 0; without severely affected donors +0.21 (p 0.393, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ABCD2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3436: ABCD2 in astrocytes, braak

power: full sample -0.13 (p 0.621, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.14 (p 0.579, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.02 (p 0.928, n 18). could be the mix.
skeptic: leave-one-out range -0.26 to -0.02, sign flips 0; without severely affected donors -0.13 (p 0.621, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ABCD2 in astrocytes.

case closed: nothing better to follow up.

loading the receipts