Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0996

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.61, p 0.083). This receipt's hash covers every field on it, plus the hash of receipt 995, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0996
    17 Oct 2026, 11:39 UTC

    PFKP

    dopamine neurons, braak

    predictionPFKP in dopamine neurons tracks Braak Lewy-body stage

    registeredcff454b7bcdfa2a5

    discovery-0.61 p=0.083 n=9

    replication-0.29 p=0.443 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.61, p 0.083)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    e77d8576d25cde90cba12f64…
    follows e611828bb0ee…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0996: PFKP in dopamine neurons, braak

power
full sample -0.43 (p 0.077, n 18), 95% CI -0.75 to +0.05. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.41 (p 0.095, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.027, n 18). not the mix.
skeptic
leave-one-out range -0.60 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.077, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PFKP in dopamine neurons.

case closed: nothing better to follow up.