Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9231

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.52, p 0.153). This receipt's hash covers every field on it, plus the hash of receipt 9230, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9231
    25 Oct 2026, 02:13 UTC

    ALDH1L1

    astrocytes, braak

    predictionALDH1L1 in astrocytes tracks Braak Lewy-body stage

    registerede8f93781ab21e2b7

    discovery+0.52 p=0.153 n=9

    replication+0.11 p=0.787 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.52, p 0.153)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d00c8ebcc55dc6c2543336f7…
    follows e4af64252d1d…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9231: ALDH1L1 in astrocytes, braak

power
full sample +0.21 (p 0.413, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.21 (p 0.413, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.21 (p 0.413, n 18). could be the mix.
skeptic
leave-one-out range +0.10 to +0.35, sign flips 0; without severely affected donors +0.21 (p 0.413, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ALDH1L1 in astrocytes.

case closed: nothing better to follow up.