Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9121

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.15, p 0.699). This receipt's hash covers every field on it, plus the hash of receipt 9120, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9121
    24 Oct 2026, 23:31 UTC

    MT1F

    dopamine neurons, braak

    predictionMT1F in dopamine neurons tracks Braak Lewy-body stage

    registeredc7223aed66d430ea

    discovery-0.15 p=0.699 n=9

    replication+0.64 p=0.063 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.15, p 0.699)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    29c78d1992126e6b1602e37e…
    follows 9048f8e81986…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9121: MT1F in dopamine neurons, braak

power
full sample +0.11 (p 0.671, n 18), 95% CI -0.38 to +0.55. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.14 (p 0.585, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.585, n 18). could be the mix.
skeptic
leave-one-out range +0.02 to +0.27, sign flips 0; without severely affected donors +0.11 (p 0.671, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MT1F in dopamine neurons.

case closed: nothing better to follow up.