Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9090

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.35, p 0.354). This receipt's hash covers every field on it, plus the hash of receipt 9089, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9090
    24 Oct 2026, 22:44 UTC

    CHL1

    dopamine neurons, braak

    predictionCHL1 in dopamine neurons tracks Braak Lewy-body stage

    registered06bdeb0c44aaff6e

    discovery+0.35 p=0.354 n=9

    replication+0.45 p=0.227 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.35, p 0.354)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    86923651c8b6b5f4873b1fad…
    follows 8628f399215d…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9090: CHL1 in dopamine neurons, braak

power
full sample +0.42 (p 0.080, n 18), 95% CI -0.05 to +0.74. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.43 (p 0.072, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.48 (p 0.046, n 18). not the mix.
skeptic
leave-one-out range +0.35 to +0.60, sign flips 0; without severely affected donors +0.42 (p 0.080, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CHL1 in dopamine neurons.

case closed: nothing better to follow up.