Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9065

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.52, p 0.151). This receipt's hash covers every field on it, plus the hash of receipt 9064, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9065
    24 Oct 2026, 22:11 UTC

    ADCY2

    astrocytes, braak

    predictionADCY2 in astrocytes tracks Braak Lewy-body stage

    registered308cfde6e40e0894

    discovery+0.52 p=0.151 n=9

    replication-0.22 p=0.565 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.52, p 0.151)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2230cb3d0edbe74e6f31f5e7…
    follows df469586f40d…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9065: ADCY2 in astrocytes, braak

power
full sample +0.08 (p 0.767, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.00 (p 0.990, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.02 (p 0.942, n 18). could be the mix.
skeptic
leave-one-out range -0.00 to +0.23, sign flips 1; without severely affected donors +0.08 (p 0.767, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADCY2 in astrocytes.

case closed: nothing better to follow up.