Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8695

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.35, p 0.361). This receipt's hash covers every field on it, plus the hash of receipt 8694, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8695
    24 Oct 2026, 13:48 UTC

    GADD45A

    dopamine neurons, braak

    predictionGADD45A in dopamine neurons tracks Braak Lewy-body stage

    registeredbbf9a70df2dfa481

    discovery-0.35 p=0.361 n=9

    replication-0.36 p=0.344 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.35, p 0.361)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6ace2ec2e9ba641007287439…
    follows 49b3921929fb…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8695: GADD45A in dopamine neurons, braak

power
full sample -0.39 (p 0.111, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.36 (p 0.142, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.18 (p 0.487, n 18). could be the mix.
skeptic
leave-one-out range -0.49 to -0.29, sign flips 0; without severely affected donors -0.39 (p 0.111, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GADD45A in dopamine neurons.

case closed: nothing better to follow up.