Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8606

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.27, p 0.489). This receipt's hash covers every field on it, plus the hash of receipt 8605, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8606
    24 Oct 2026, 11:44 UTC

    TYK2

    dopamine neurons, braak

    predictionTYK2 in dopamine neurons tracks Braak Lewy-body stage

    registered6903b01c447d9517

    discovery-0.27 p=0.489 n=9

    replication-0.36 p=0.347 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.27, p 0.489)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b4e0cd2894e3b8fd63886f27…
    follows 389e206329a0…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8606: TYK2 in dopamine neurons, braak

power
full sample -0.31 (p 0.218, n 18), 95% CI -0.68 to +0.19. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.40 (p 0.101, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.137, n 18). could be the mix.
skeptic
leave-one-out range -0.47 to -0.24, sign flips 0; without severely affected donors -0.31 (p 0.218, n 18). fragile.
cell type
strongest in OPCs: -0.71 (p 9.6e-4, n 18) vs -0.31 in dopamine neurons. proposing OPCs.
axis
no measure beats "tracks Braak Lewy-body stage" for TYK2 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TYK2 · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.05 p 0.859 (needs p < 2.5e-4)