Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8533

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.63, p 0.068). This receipt's hash covers every field on it, plus the hash of receipt 8532, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8533
    24 Oct 2026, 10:02 UTC

    SENP1

    dopamine neurons, braak

    predictionSENP1 in dopamine neurons tracks Braak Lewy-body stage

    registered5f66441801cd925b

    discovery+0.63 p=0.068 n=9

    replication+0.52 p=0.153 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.63, p 0.068)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    66822c40e35985011ca7edb9…
    follows 2fb2fbeab78d…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8533: SENP1 in dopamine neurons, braak

power
full sample +0.58 (p 0.013, n 18), 95% CI +0.15 to +0.82. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.57 (p 0.013, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.57 (p 0.013, n 18). not the mix.
skeptic
leave-one-out range +0.52 to +0.66, sign flips 0; without severely affected donors +0.58 (p 0.013, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SENP1 in dopamine neurons.

case closed: nothing better to follow up.