Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0842

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.37, p 0.329). This receipt's hash covers every field on it, plus the hash of receipt 841, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0842
    17 Oct 2026, 07:58 UTC

    CACNA1A

    oligodendrocytes, braak

    predictionCACNA1A in oligodendrocytes tracks Braak Lewy-body stage

    registered061f5728591abff8

    discovery-0.37 p=0.329 n=9

    replication+0.14 p=0.718 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.37, p 0.329)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f5ff570e83c1c420eb7a236e…
    follows 1ad6ffb8492e…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0842: CACNA1A in oligodendrocytes, braak

power
full sample -0.15 (p 0.555, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.16 (p 0.521, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.30 (p 0.232, n 18). could be the mix.
skeptic
leave-one-out range -0.29 to -0.03, sign flips 0; without severely affected donors -0.15 (p 0.555, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CACNA1A in oligodendrocytes.

case closed: nothing better to follow up.