Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0823

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.52, p 0.148). This receipt's hash covers every field on it, plus the hash of receipt 822, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0823
    17 Oct 2026, 07:31 UTC

    SLC39A10

    microglia, braak

    predictionSLC39A10 in microglia tracks Braak Lewy-body stage

    registeredc3d793e2292a160e

    discovery-0.52 p=0.148 n=9

    replication-0.14 p=0.725 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.52, p 0.148)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    1bcd46c1345b5e3c16a9a05c…
    follows ad037930e6cc…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0823: SLC39A10 in microglia, braak

power
full sample -0.41 (p 0.087, n 18), 95% CI -0.74 to +0.07. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.44 (p 0.064, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.33 (p 0.176, n 18). could be the mix.
skeptic
leave-one-out range -0.54 to -0.32, sign flips 0; without severely affected donors -0.41 (p 0.087, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC39A10 in microglia.

case closed: nothing better to follow up.