Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8101

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.35, p 0.360). This receipt's hash covers every field on it, plus the hash of receipt 8100, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8101
    24 Oct 2026, 01:08 UTC

    PYCR3

    dopamine neurons, braak

    predictionPYCR3 in dopamine neurons tracks Braak Lewy-body stage

    registered888555c43683d4b1

    discovery-0.35 p=0.360 n=9

    replication+0.20 p=0.607 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.35, p 0.360)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6e7648f69667b3887dfd9246…
    follows dfefeffaeaf6…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8101: PYCR3 in dopamine neurons, braak

power
full sample -0.09 (p 0.722, n 18), 95% CI -0.53 to +0.39. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.08 (p 0.754, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.23 (p 0.365, n 18). could be the mix.
skeptic
leave-one-out range -0.17 to +0.03, sign flips 4; without severely affected donors -0.09 (p 0.722, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PYCR3 in dopamine neurons.

case closed: nothing better to follow up.