Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8048

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.36, p 0.347). This receipt's hash covers every field on it, plus the hash of receipt 8047, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8048
    23 Oct 2026, 23:59 UTC

    SMAD7

    dopamine neurons, braak

    predictionSMAD7 in dopamine neurons tracks Braak Lewy-body stage

    registered79b1ff5d186baf2f

    discovery-0.36 p=0.347 n=9

    replication-0.42 p=0.266 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.36, p 0.347)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3ef8821bc8e018955eedc6fb…
    follows 81aa2c88a568…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8048: SMAD7 in dopamine neurons, braak

power
full sample -0.36 (p 0.137, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.41 (p 0.089, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.046, n 18). not the mix.
skeptic
leave-one-out range -0.51 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.137, n 18). fragile.
cell type
strongest in oligodendrocytes: -0.69 (p 0.0016, n 18) vs -0.36 in dopamine neurons. proposing oligodendrocytes.
axis
no measure beats "tracks Braak Lewy-body stage" for SMAD7 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SMAD7 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.40 p 0.155 (needs p < 2.6e-4)