Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7665

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.45, p 0.230). This receipt's hash covers every field on it, plus the hash of receipt 7664, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7665
    23 Oct 2026, 15:19 UTC

    ACTN4

    oligodendrocytes, braak

    predictionACTN4 in oligodendrocytes tracks Braak Lewy-body stage

    registered23dd9c985831f1b5

    discovery-0.45 p=0.230 n=9

    replication-0.43 p=0.253 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.45, p 0.230)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6fe6f6a3e6f14547980e674f…
    follows 67101e20efb5…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7665: ACTN4 in oligodendrocytes, braak

power
full sample -0.43 (p 0.074, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.47 (p 0.050, n 18). holds up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.42 (p 0.082, n 18). could be the mix.
skeptic
leave-one-out range -0.51 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.074, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ACTN4 in oligodendrocytes.

case closed: nothing better to follow up.