Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7528

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.03, p 0.947). This receipt's hash covers every field on it, plus the hash of receipt 7527, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7528
    23 Oct 2026, 12:15 UTC

    WDR11

    dopamine neurons, braak

    predictionWDR11 in dopamine neurons tracks Braak Lewy-body stage

    registereddf29a33b47e3b4e3

    discovery+0.03 p=0.947 n=9

    replication+0.02 p=0.964 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.03, p 0.947)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3d991fd26d4a25e01e3899db…
    follows 5e9ea9f0ca44…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7528: WDR11 in dopamine neurons, braak

power
full sample +0.06 (p 0.814, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.976, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.935, n 18). could be the mix.
skeptic
leave-one-out range -0.06 to +0.17, sign flips 2; without severely affected donors +0.06 (p 0.814, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for WDR11 in dopamine neurons.

case closed: nothing better to follow up.