Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7459

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.20, p 0.613). This receipt's hash covers every field on it, plus the hash of receipt 7458, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7459
    23 Oct 2026, 10:38 UTC

    RIPK3

    microglia, braak

    predictionRIPK3 in microglia tracks Braak Lewy-body stage

    registered7a9b8f9a5e5e1478

    discovery+0.20 p=0.613 n=9

    replication-0.26 p=0.499 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.20, p 0.613)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    e415c738925086e6bfdc1b7b…
    follows 907514ac40b3…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7459: RIPK3 in microglia, braak

power
full sample -0.05 (p 0.840, n 18), 95% CI -0.51 to +0.43. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.983, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.02 (p 0.935, n 18). could be the mix.
skeptic
leave-one-out range -0.17 to +0.10, sign flips 2; without severely affected donors -0.05 (p 0.840, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RIPK3 in microglia.

case closed: nothing better to follow up.