Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7136

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.24, p 0.529). This receipt's hash covers every field on it, plus the hash of receipt 7135, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7136
    23 Oct 2026, 03:31 UTC

    DNMT3B

    dopamine neurons, braak

    predictionDNMT3B in dopamine neurons tracks Braak Lewy-body stage

    registeredd6eb7c1cb7b94e83

    discovery+0.24 p=0.529 n=9

    replication-0.49 p=0.181 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.24, p 0.529)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ac1641d9e1a17112eb9261dd…
    follows fd5a7b992a3c…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7136: DNMT3B in dopamine neurons, braak

power
full sample -0.16 (p 0.521, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.15 (p 0.561, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.337, n 18). could be the mix.
skeptic
leave-one-out range -0.27 to -0.05, sign flips 0; without severely affected donors -0.16 (p 0.521, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DNMT3B in dopamine neurons.

case closed: nothing better to follow up.