Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0691

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.09, p 0.820). This receipt's hash covers every field on it, plus the hash of receipt 690, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0691
    17 Oct 2026, 04:26 UTC

    TNK2

    oligodendrocytes, braak

    predictionTNK2 in oligodendrocytes tracks Braak Lewy-body stage

    registered4cc20cac1058711c

    discovery+0.09 p=0.820 n=9

    replication-0.63 p=0.067 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.09, p 0.820)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    88471e4e4762a2a148a38f45…
    follows bc469971a13a…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0691: TNK2 in oligodendrocytes, braak

power
full sample -0.31 (p 0.207, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.30 (p 0.228, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.25 (p 0.323, n 18). could be the mix.
skeptic
leave-one-out range -0.49 to -0.22, sign flips 0; without severely affected donors -0.31 (p 0.207, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TNK2 in oligodendrocytes.

case closed: nothing better to follow up.