Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6895

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.04, p 0.912). This receipt's hash covers every field on it, plus the hash of receipt 6894, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6895
    22 Oct 2026, 22:55 UTC

    ADH4

    dopamine neurons, braak

    predictionADH4 in dopamine neurons tracks Braak Lewy-body stage

    registered9d45dedf29a3335d

    discovery-0.04 p=0.912 n=9

    replication-0.13 p=0.741 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.04, p 0.912)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    0be29911e87835e2c7fadab8…
    follows 49cea4f3937b…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6895: ADH4 in dopamine neurons, braak

power
full sample +0.07 (p 0.781, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.06 (p 0.807, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.715, n 18). could be the mix.
skeptic
leave-one-out range -0.03 to +0.19, sign flips 1; without severely affected donors +0.07 (p 0.781, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADH4 in dopamine neurons.

case closed: nothing better to follow up.