Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6868

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.12, p 0.767). This receipt's hash covers every field on it, plus the hash of receipt 6867, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6868
    22 Oct 2026, 22:19 UTC

    TMED5

    dopamine neurons, braak

    predictionTMED5 in dopamine neurons tracks Braak Lewy-body stage

    registered45792e35f5ce7683

    discovery-0.12 p=0.767 n=9

    replication+0.39 p=0.293 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.12, p 0.767)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c07c771b7b484b0b55e0adbd…
    follows 5dc7a4685a5d…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6868: TMED5 in dopamine neurons, braak

power
full sample +0.17 (p 0.504, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.13 (p 0.597, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.493, n 18). could be the mix.
skeptic
leave-one-out range +0.09 to +0.35, sign flips 0; without severely affected donors +0.17 (p 0.504, n 18). fragile.
cell type
strongest in oligodendrocytes: +0.60 (p 0.0086, n 18) vs +0.17 in dopamine neurons. proposing oligodendrocytes.
axis
no measure beats "tracks Braak Lewy-body stage" for TMED5 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TMED5 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.68 p 0.016 (needs p < 3.0e-4)