Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6651

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.11, p 0.784). This receipt's hash covers every field on it, plus the hash of receipt 6650, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6651
    22 Oct 2026, 17:22 UTC

    HPSE2

    dopamine neurons, braak

    predictionHPSE2 in dopamine neurons tracks Braak Lewy-body stage

    registered56c1c08261ab756d

    discovery+0.11 p=0.784 n=9

    replication+0.29 p=0.456 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.11, p 0.784)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    5bd953f1604a0ffdd5c4cce3…
    follows 39712ba47521…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6651: HPSE2 in dopamine neurons, braak

power
full sample +0.24 (p 0.341, n 18), 95% CI -0.26 to +0.63. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.23 (p 0.351, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.22 (p 0.379, n 18). could be the mix.
skeptic
leave-one-out range +0.17 to +0.42, sign flips 0; without severely affected donors +0.24 (p 0.341, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HPSE2 in dopamine neurons.

case closed: nothing better to follow up.