Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6626

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.10, p 0.805). This receipt's hash covers every field on it, plus the hash of receipt 6625, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6626
    22 Oct 2026, 16:49 UTC

    RGS5

    dopamine neurons, braak

    predictionRGS5 in dopamine neurons tracks Braak Lewy-body stage

    registered1cf173147ab36d6a

    discovery+0.10 p=0.805 n=9

    replication+0.74 p=0.023 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.10, p 0.805)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b10daaa2ec6685a8f8bf8d98…
    follows 0106d185329b…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6626: RGS5 in dopamine neurons, braak

power
full sample +0.41 (p 0.093, n 18), 95% CI -0.07 to +0.73. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.41 (p 0.087, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.145, n 18). could be the mix.
skeptic
leave-one-out range +0.33 to +0.62, sign flips 0; without severely affected donors +0.41 (p 0.093, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RGS5 in dopamine neurons.

case closed: nothing better to follow up.