Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6592

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.46, p 0.209). This receipt's hash covers every field on it, plus the hash of receipt 6591, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6592
    22 Oct 2026, 16:05 UTC

    CYP4F11

    astrocytes, braak

    predictionCYP4F11 in astrocytes tracks Braak Lewy-body stage

    registered218f548c15b610d7

    discovery-0.46 p=0.209 n=9

    replication-0.06 p=0.877 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.46, p 0.209)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    54191222f0200803e13b49f2…
    follows a3626963b853…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6592: CYP4F11 in astrocytes, braak

power
full sample -0.24 (p 0.328, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.23 (p 0.351, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.23 (p 0.360, n 18). could be the mix.
skeptic
leave-one-out range -0.41 to -0.15, sign flips 0; without severely affected donors -0.24 (p 0.328, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CYP4F11 in astrocytes.

case closed: nothing better to follow up.