Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6406

A sealed prediction that did not hold.

did not replicate (discovery -0.84 p 0.0043; held-out -0.22 p 0.570). This receipt's hash covers every field on it, plus the hash of receipt 6405, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6406
    22 Oct 2026, 11:55 UTC

    C4A

    dopamine neurons, braak

    predictionC4A in dopamine neurons tracks Braak Lewy-body stage

    registered990c8a1bc8eb0069

    discovery-0.84 p=0.0043 n=9

    replication-0.22 p=0.570 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.84 p 0.0043; held-out -0.22 p 0.570)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    af7586e6485087b5a7ebaf86…
    follows a5c4f57b1486…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6406: C4A in dopamine neurons, braak

power
full sample -0.57 (p 0.013, n 18), 95% CI -0.82 to -0.14. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.59 (p 0.011, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.72 (p 7.0e-4, n 18). not the mix.
skeptic
leave-one-out range -0.67 to -0.51, sign flips 0; without severely affected donors -0.57 (p 0.013, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for C4A in dopamine neurons.

case closed: nothing better to follow up.