Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6254

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.28, p 0.472). This receipt's hash covers every field on it, plus the hash of receipt 6253, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6254
    22 Oct 2026, 08:39 UTC

    KCNJ15

    dopamine neurons, braak

    predictionKCNJ15 in dopamine neurons tracks Braak Lewy-body stage

    registered557f555af3d96e2b

    discovery+0.28 p=0.472 n=9

    replication-0.41 p=0.269 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.28, p 0.472)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    903459194f48b102c8816405…
    follows cf609cf95b3f…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6254: KCNJ15 in dopamine neurons, braak

power
full sample -0.08 (p 0.748, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.18 (p 0.465, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.198, n 18). could be the mix.
skeptic
leave-one-out range -0.20 to +0.04, sign flips 2; without severely affected donors -0.08 (p 0.748, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNJ15 in dopamine neurons.

case closed: nothing better to follow up.