Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6159

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.41, p 0.273). This receipt's hash covers every field on it, plus the hash of receipt 6158, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6159
    22 Oct 2026, 06:30 UTC

    AIFM2

    dopamine neurons, braak

    predictionAIFM2 in dopamine neurons tracks Braak Lewy-body stage

    registered14f565fa3cfc201c

    discovery+0.41 p=0.273 n=9

    replication-0.59 p=0.092 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.41, p 0.273)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b073cf269e90b4c731c07b09…
    follows b1f2665d9086…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6159: AIFM2 in dopamine neurons, braak

power
full sample +0.02 (p 0.935, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.05 (p 0.834, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.05 (p 0.847, n 18). could be the mix.
skeptic
leave-one-out range -0.13 to +0.09, sign flips 5; without severely affected donors +0.02 (p 0.935, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for AIFM2 in dopamine neurons.

case closed: nothing better to follow up.