Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5898

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.08, p 0.838). This receipt's hash covers every field on it, plus the hash of receipt 5897, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5898
    22 Oct 2026, 01:21 UTC

    MYO9A

    dopamine neurons, braak

    predictionMYO9A in dopamine neurons tracks Braak Lewy-body stage

    registeredf8fdc9e20b872e75

    discovery+0.08 p=0.838 n=9

    replication+0.57 p=0.108 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.08, p 0.838)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    93ef63d90841b8d30b49636e…
    follows 35d0e3272ae0…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5898: MYO9A in dopamine neurons, braak

power
full sample +0.27 (p 0.273, n 18), 95% CI -0.22 to +0.66. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.22 (p 0.389, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.258, n 18). could be the mix.
skeptic
leave-one-out range +0.18 to +0.39, sign flips 0; without severely affected donors +0.27 (p 0.273, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MYO9A in dopamine neurons.

case closed: nothing better to follow up.