Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5413

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.21, p 0.589). This receipt's hash covers every field on it, plus the hash of receipt 5412, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5413
    21 Oct 2026, 14:43 UTC

    S100A10

    dopamine neurons, braak

    predictionS100A10 in dopamine neurons tracks Braak Lewy-body stage

    registered6a4234d9f434e741

    discovery+0.21 p=0.589 n=9

    replication-0.25 p=0.520 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.21, p 0.589)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f98df9bb47a68b3ca9648979…
    follows 80d8c2fbbc0e…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5413: S100A10 in dopamine neurons, braak

power
full sample -0.00 (p 0.990, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.12 (p 0.627, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.16 (p 0.538, n 18). could be the mix.
skeptic
leave-one-out range -0.10 to +0.15, sign flips 9; without severely affected donors -0.00 (p 0.990, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for S100A10 in dopamine neurons.

case closed: nothing better to follow up.