Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5306

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.45, p 0.219). This receipt's hash covers every field on it, plus the hash of receipt 5305, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5306
    21 Oct 2026, 12:22 UTC

    CLIP2

    dopamine neurons, braak

    predictionCLIP2 in dopamine neurons tracks Braak Lewy-body stage

    registeredd18db11b8f2f9d9c

    discovery-0.45 p=0.219 n=9

    replication+0.18 p=0.637 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.45, p 0.219)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    0576c28dfc431b771693f90f…
    follows d17ababa07d8…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5306: CLIP2 in dopamine neurons, braak

power
full sample -0.11 (p 0.671, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.08 (p 0.761, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.787, n 18). could be the mix.
skeptic
leave-one-out range -0.24 to -0.01, sign flips 0; without severely affected donors -0.11 (p 0.671, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CLIP2 in dopamine neurons.

case closed: nothing better to follow up.