Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5103

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.48, p 0.195). This receipt's hash covers every field on it, plus the hash of receipt 5102, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5103
    21 Oct 2026, 08:06 UTC

    UPK1A

    dopamine neurons, braak

    predictionUPK1A in dopamine neurons tracks Braak Lewy-body stage

    registered926ee5d5d4a9fbd0

    discovery-0.48 p=0.195 n=9

    replication-0.23 p=0.549 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.48, p 0.195)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    aeca1edef254e38ec8a9bbcf…
    follows 1ecfd2615bf9…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5103: UPK1A in dopamine neurons, braak

power
full sample -0.29 (p 0.235, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.26 (p 0.298, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.145, n 18). could be the mix.
skeptic
leave-one-out range -0.39 to -0.21, sign flips 0; without severely affected donors -0.29 (p 0.235, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for UPK1A in dopamine neurons.

case closed: nothing better to follow up.