Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4815

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.33, p 0.386). This receipt's hash covers every field on it, plus the hash of receipt 4814, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4815
    21 Oct 2026, 02:23 UTC

    NT5E

    dopamine neurons, braak

    predictionNT5E in dopamine neurons tracks Braak Lewy-body stage

    registered87fdca44d657b192

    discovery+0.33 p=0.386 n=9

    replication+0.14 p=0.722 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.33, p 0.386)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    08f18f6e16d20530eca87cc8…
    follows 6b2330db5dd9…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4815: NT5E in dopamine neurons, braak

power
full sample +0.30 (p 0.232, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.31 (p 0.211, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.16 (p 0.532, n 18). could be the mix.
skeptic
leave-one-out range +0.22 to +0.46, sign flips 0; without severely affected donors +0.30 (p 0.232, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NT5E in dopamine neurons.

case closed: nothing better to follow up.