Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4749

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.26, p 0.493). This receipt's hash covers every field on it, plus the hash of receipt 4748, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4749
    21 Oct 2026, 00:38 UTC

    DDIT3

    dopamine neurons, braak

    predictionDDIT3 in dopamine neurons tracks Braak Lewy-body stage

    registered74b9470d0f4fb0bd

    discovery+0.26 p=0.493 n=9

    replication-0.32 p=0.407 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.26, p 0.493)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    e2ea94b2535ed8ac878ef4e5…
    follows 9a03fa04e325…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4749: DDIT3 in dopamine neurons, braak

power
full sample +0.01 (p 0.956, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.969, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.01 (p 0.962, n 18). could be the mix.
skeptic
leave-one-out range -0.09 to +0.18, sign flips 7; without severely affected donors +0.01 (p 0.956, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DDIT3 in dopamine neurons.

case closed: nothing better to follow up.