Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4691

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.01, p 0.982). This receipt's hash covers every field on it, plus the hash of receipt 4690, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4691
    20 Oct 2026, 23:15 UTC

    DNASE2B

    dopamine neurons, braak

    predictionDNASE2B in dopamine neurons tracks Braak Lewy-body stage

    registered9613f28e84b87f52

    discovery-0.01 p=0.982 n=9

    replication+0.15 p=0.699 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.01, p 0.982)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    4b2d25b0f2af238b05463bae…
    follows 49d950175e6b…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4691: DNASE2B in dopamine neurons, braak

power
full sample +0.01 (p 0.962, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.05 (p 0.854, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.942, n 18). could be the mix.
skeptic
leave-one-out range -0.10 to +0.14, sign flips 7; without severely affected donors +0.01 (p 0.962, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DNASE2B in dopamine neurons.

case closed: nothing better to follow up.