Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4667

A sealed prediction that did not hold.

did not replicate (discovery +0.91 p 6.6e-4; held-out +0.08 p 0.838). This receipt's hash covers every field on it, plus the hash of receipt 4666, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4667
    20 Oct 2026, 22:42 UTC

    MYH10

    dopamine neurons, braak

    predictionMYH10 in dopamine neurons tracks Braak Lewy-body stage

    registered0033c690536a8c5c

    discovery+0.91 p=6.6e-4 n=9

    replication+0.08 p=0.838 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.91 p 6.6e-4; held-out +0.08 p 0.838)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    03a368d1a8ebc6f9b3cdc4d6…
    follows e8a5652e774b…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4667: MYH10 in dopamine neurons, braak

power
full sample +0.29 (p 0.250, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.27 (p 0.277, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.32 (p 0.194, n 18). could be the mix.
skeptic
leave-one-out range +0.20 to +0.47, sign flips 0; without severely affected donors +0.29 (p 0.250, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MYH10 in dopamine neurons.

case closed: nothing better to follow up.