Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0448

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.12, p 0.750). This receipt's hash covers every field on it, plus the hash of receipt 447, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0448
    17 Oct 2026, 01:04 UTC

    CLK2

    astrocytes, braak

    predictionCLK2 in astrocytes tracks Braak Lewy-body stage

    registered171d62b217221d0a

    discovery+0.12 p=0.750 n=9

    replication+0.20 p=0.607 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.12, p 0.750)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f05ae1c5995e653e4badbdd7…
    follows fbcc70085fa2…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0448: CLK2 in astrocytes, braak

power
full sample +0.04 (p 0.881, n 18), 95% CI -0.44 to +0.50. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.11 (p 0.671, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.10 (p 0.702, n 18). could be the mix.
skeptic
leave-one-out range -0.07 to +0.19, sign flips 6; without severely affected donors +0.04 (p 0.881, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CLK2 in astrocytes.

case closed: nothing better to follow up.