Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4444

A sealed prediction that did not hold.

did not replicate (discovery -0.72 p 0.029; held-out -0.26 p 0.493). This receipt's hash covers every field on it, plus the hash of receipt 4443, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4444
    20 Oct 2026, 17:39 UTC

    FOS

    dopamine neurons, braak

    predictionFOS in dopamine neurons tracks Braak Lewy-body stage

    registerede334f930f3f689bd

    discovery-0.72 p=0.029 n=9

    replication-0.26 p=0.493 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.72 p 0.029; held-out -0.26 p 0.493)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    ff04af6d1e26744959130394…
    follows 507c2e4d68c2…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4444: FOS in dopamine neurons, braak

power
full sample -0.38 (p 0.120, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.42 (p 0.084, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.42 (p 0.082, n 18). could be the mix.
skeptic
leave-one-out range -0.51 to -0.28, sign flips 0; without severely affected donors -0.38 (p 0.120, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FOS in dopamine neurons.

case closed: nothing better to follow up.