Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4328

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.18, p 0.646). This receipt's hash covers every field on it, plus the hash of receipt 4327, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4328
    20 Oct 2026, 15:05 UTC

    SLC25A12

    dopamine neurons, braak

    predictionSLC25A12 in dopamine neurons tracks Braak Lewy-body stage

    registeredb573dc315431dfee

    discovery+0.18 p=0.646 n=9

    replication+0.77 p=0.015 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.18, p 0.646)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ab4b1b2829f425e3d537d4bd…
    follows 701ebd1c7cc2…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4328: SLC25A12 in dopamine neurons, braak

power
full sample +0.43 (p 0.072, n 18), 95% CI -0.04 to +0.75. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.48 (p 0.043, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.48 (p 0.043, n 18). not the mix.
skeptic
leave-one-out range +0.35 to +0.57, sign flips 0; without severely affected donors +0.43 (p 0.072, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC25A12 in dopamine neurons.

case closed: nothing better to follow up.